European Commission's judge that Apple has to pay Ireland an overdue tax bill up to 13 billion Euro actually has triggered a quarrel between the U.S. and European Union. ANBOUND research team suggests that apart from this dispute, the factors that hinder the TPP and TTIP are likely to worsen the trade and investment relation between the US and EU. If it realized, the framework of global trade and investment will be significantly affected. But for China, it will be a good strategic opportunity if TPP and TTIP were both failed.